Combined Harmony Performance Across All Clinical Studies1-3, 7-12

  • Harmony has a less than 0.1% false-positive rate for trisomies 13, 18 and 21
  • This means fewer than 1 in 1000 Harmony NIPT yields a false-positive result
  • With conventional screening, as many as 1 in 20 women will receive a false-positive result 4

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Greater clarity

Harmony NIPT has exceptional accuracy, bringing clarity to genetic testing for common trisomies.

  • In blinded clinical trials, Harmony correctly identified over 99% of cases of trisomy 21.1-2
  • Conventional screening tests can miss 15% or more of trisomy 21 cases.4

A unique methodology

Harmony uses a targeted technological approach to DNA assessment—focusing on analyzing only the specific chromosomes of interest and the precise measurement of fetal DNA using SNPs (single nucleotide polymorphisms) to achieve greater accuracy.7
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Any age or risk category*

Harmony NIPT is clinically validated for use in pregnant women (of any age or risk category*) to assess the probability of fetal trisomies 21, 18 and 13.1-3

  • Studied extensively in blinded prospective trials including more than 22 000 women of all ages.1-2,8-9,11
  • Over 3 000 000 pregnancies tested worldwide.

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How to offer harmony to your patients, workflow

*Age groups both over and under 35 years of age (studies have included women aged 18-48).

**Harmony is designed to assess probability for trisomy 21, 18, and 13 and sex chromosome aneuploidy. It cannot exclude all genetic defects nor detect every problem that may occur in pregnancy.

  1. Norton et al. N Engl J Med. 2015 Apr 23;372(17):1589-97.
  2. Norton et al. Am J Obstet Gynecol. 2012 Aug;207(2):137.e1-8.
  3. Ashoor et al. Ultrasound Obstet Gynecol. 2013 Jan;41(1):21-5.
  4. ACOG Committee on Practice Bulletin No. 77. Obstet Gynecol 2007;109:217-27.
  5. Wax et al. J Clin Ultrasound. 2015 Jan;43(1):1-6.
  6. Lou et al. Acta Obstet Gynecol Scand. 2015;94(1):15-27.
  7. Sparks et al. Am J Obstet Gynecol. 2012 Apr;206(4):319.e1-9.
  8. Verweij et al. Prenat Diagn. 2013 Oct;33(10):996-1001.
  9. Nicolaides et al. Am J Obstet Gynecol. 2012 Nov;207(5):374.e1-6.
  10. Ashoor et al. Am J Obstet Gynecol. 2012 Apr;206(4):322.e1-5.
  11. Gil et al. Fetal Diagn Ther. 2014;35:204-11.
  12. Juneau et al. Fetal Diagn Ther. 2014;36(4):282-6.